“Gene expression profiles as a non-invasive measure of adult cochlear implant performance”
Justin Cottrell, Lianna Kyriakopoulou, Varia Sajeniouk, Joseph Chen, Vincent Lin, Andrew Dimitrijevic, Trung Le
Objectives Cochlear implant (CI) recipients for severe-to-profound sensorineural hearing loss demonstrate a wide range in speech performance, possibly driven by the degree of neural degeneration. Genetic factors may be a significant independent predictor of spiral ganglion health and this outcome variability. We sought to determine the relationship between genetic variants and CI performance among adult cochlear implant recipients.
Methods Blood samples collected from study participants meeting inclusion criteria were tested for a novel panel of genetic variants using high-throughput sequencing. AzBio sentence, Consonant-vowel-Nucleus-Consonant, and Hearing-in-Noise tests were measured for speech understanding pre-operatively and at 3, 6, and 12 months post-operatively.
Results Eighteen cochlear implant patients underwent genetic testing and speech understanding measurements to identify genes that provide predictive value for cochlear implant speech outcomes.
Conclusions This study helps to elucidate the role of genetic testing as a non-invasive measure of spiral ganglion health to improve CI performance predictions in patients.
- By the end of this session, Otolaryngology – Head and Neck Surgeons will have a better understanding of how genetic testing could be utilized as a tool for predicting cochlear implant outcomes
- By the end of this session, Otolaryngology – Head and Neck Surgeons will be able to consider the significance of genetic variants in the sensory partition (organ of Corti and synapse) and the neural partition (spiral ganglion)
- By the end of this session, Otolaryngology – Head and Neck Surgeons will better understand the role that genetics play in hearing loss
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Authors' Contact Details
Corresponding Author: Dr. Justin Cottrell (firstname.lastname@example.org)
Senior Author: Dr. Trung Le