“Transoral robotic surgery versus chemoradiation treatment in oropharyngeal cancer: case-matched comparison of survival and swallowing outcomes”
Connor Sommerfeld, Caroline Jeffery, Jessica Clark, Daniel O’Connell, Jeffrey Harris, Hadi Seikaly, Vincent Biron
Objectives: To compare survival and swallowing outcomes of transoral robotic surgery (TORS) versus chemoradiation (CRT) in patients with oropharyngeal squamous cell carcinoma (OPSCC).
Methods: From May 2014 to October 2018, data was prospectively collected from OPSCC patients treated with curative intent by TORS (+/-post-operative RT/CRT) or CRT. Surgical and non-surgical treatment groups were case-matched for overall stage, p16 and smoking status. Videofluoroscopic functional evaluation of swallowing (VFSS) measurements, g-tube dependence and survival outcomes were compared.
Results: A total of 75 patients treated with TORS were 1:1 case-matched with 70 patients who received CRT. TORS patients had a significantly higher recurrence free (RFS) and overall survival (OS) at 3 years (RFS=91.7%, OS=92.9%) compared to CRT patients (RFS=86.0%, OS=77.2%). TORS patients also had significantly lower g-tube dependence 6-12 months post-treatment.
Conclusions: This study suggests that OPSCC patients undergoing TORS may have improved survival and swallowing outcomes compared patients treated with CRT.
- By the end of the presentation, the audience will be able to compare functional outcomes of transoral robotic surgery versus chemoradiotherapy.
- By the end of the presentation, the audience will be able to compare recurrence free survival rates of transoral robotic surgery versus chemoradiotherapy.
- By the end of the presentation, the audience will be able to consider transoral robotic surgery as an effective surgical alternative to chemoradiotherapy for p16-positive oropharyngeal squamous cell carcinoma.
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Corresponding Author: Dr. Vincent Biron
Senior Author: Dr. Vincent Biron
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