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“Transoral robotic surgery versus chemoradiation treatment in oropharyngeal cancer: case-matched comparison of survival and swallowing outcomes”

Connor Sommerfeld, Caroline Jeffery, Jessica Clark, Daniel O’Connell, Jeffrey Harris, Hadi Seikaly, Vincent Biron

Abstract

Objectives: To compare survival and swallowing outcomes of transoral robotic surgery (TORS) versus chemoradiation (CRT) in patients with oropharyngeal squamous cell carcinoma (OPSCC).

 

Methods: From May 2014 to October 2018, data was prospectively collected from OPSCC patients treated with curative intent by TORS (+/-post-operative RT/CRT) or CRT.  Surgical and non-surgical treatment groups were case-matched for overall stage, p16 and smoking status.  Videofluoroscopic functional evaluation of swallowing (VFSS) measurements, g-tube dependence and survival outcomes were compared.

 

Results: A total of 75 patients treated with TORS were 1:1 case-matched with 70 patients who received CRT.  TORS patients had a significantly higher recurrence free (RFS) and overall survival (OS) at 3 years (RFS=91.7%, OS=92.9%) compared to CRT patients (RFS=86.0%, OS=77.2%).  TORS patients also had significantly lower g-tube dependence 6-12 months post-treatment.

 

Conclusions: This study suggests that OPSCC patients undergoing TORS may have improved survival and swallowing outcomes compared patients treated with CRT.

Learning Objectives

  1. By the end of the presentation, the audience will be able to compare functional outcomes of transoral robotic surgery versus chemoradiotherapy.
  2. By the end of the presentation, the audience will be able to compare recurrence free survival rates of transoral robotic surgery versus chemoradiotherapy.
  3. By the end of the presentation, the audience will be able to consider transoral robotic surgery as an effective surgical alternative to chemoradiotherapy for p16-positive oropharyngeal squamous cell carcinoma.

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Scheduling Details

This 7 minute presentation is scheduled to take place on June 3, 2019 at 16:25 in the Hall C.

Authors' Contact Details

Corresponding Author: Dr. Vincent Biron

Senior Author: Dr. Vincent Biron

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