To investigate the role of Mitomycin C application in the prevention of subglottic stenosis (SGS) following injury to the subglottic area (SGA) in an experimental animal study using light microscope.
Subjects: 13 New Zealand white rabbits weighting between 1500-2500 g.
Aprospective experimental animal study
Rabbits were divided into 3 groups: control (C), low dose (L), and high dose (H). Subglottic injury was applied to the (L) and (H) groups under anesthesia. Then Mitomycin C was applied to them with the doses of 0.4 mg/ml and 4 mg/ml respectively. After 6 week a sample of the SGA was sent for light microscope.
The H group rabbits had clinical obstruction and gross SGS. Histological examination of L group showed degradation of architecture which was worse in the H group compared to the control group
Mitomycin C has negative effect on SGA
- Review the different management options for treating subglottic stenosis
- Highlighting the different types and causes of subglottic stenosis
- Describing a method to induce subglottic stenosis in rabbit models for experimental studies
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Authors' Contact Details
Corresponding Author: Dr. Mariam Al Sheikah
Senior Author: Dr. Talal Al Khatib
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