Scheduled Presentations by Date

“The Role of Mitomycin C in the Prevention of Subglottic Stenosis: An experimental Animal Study using Light Microscope.” Mariam Al Sheikah, Talal Al Khatib, Abdulrahman Al Thubaiti, Abdulrahman Al Juhani

Abstract

Objective:

To investigate the role of  Mitomycin C application  in the prevention of subglottic stenosis (SGS) following injury to the subglottic area (SGA) in an experimental animal study using light microscope.

Method:

Subjects: 13 New Zealand white rabbits weighting between 1500-2500 g.

Aprospective experimental animal study

Rabbits were divided into 3 groups: control (C), low dose (L), and high dose (H). Subglottic injury was applied to the  (L) and (H) groups under anesthesia. Then Mitomycin C was applied to them with the doses of 0.4 mg/ml and 4 mg/ml respectively. After 6 week a sample of the SGA was sent for light microscope.

 

Results:

The H group rabbits had clinical obstruction and gross SGS.  Histological examination of L group showed degradation of architecture which was worse in the H group  compared to the control group

 

Conclusion:

Mitomycin C has negative effect on SGA

Learning Objectives

  1. Review the different management options for treating subglottic stenosis
  2. Highlighting the different types and causes of subglottic stenosis
  3. Describing a method to induce subglottic stenosis in rabbit models for experimental studies

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Scheduling Details

This 7 minute presentation is scheduled to take place on June 4, 2019 at 10:42 in the Salon 8.

Authors' Contact Details

Corresponding Author: Dr. Mariam Al Sheikah

Senior Author: Dr. Talal Al Khatib

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