Background: Neoadjuvant chemotherapy followed by surgery in the treatment of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) is newly being investigated. The objective of this study is to ascertain the response to neoadjuvant chemotherapy and the associationof tumor volume reduction on imaging to predict pathologic response.
Methods: A prospective observational study of patients with HPV-positive OPSCC enrolled in a clinical trial of neoadjuvant chemotherapy followed by surgery was performed. The diagnostic utility of imaging in predicting the complete pathologic response (CR) at the primary and nodal sites was assessed using pre and post-chemotherapy imaging.
Results: 43.6% (24/55) of patients had a CR at all sites. An estimated volume reduction of the primary tumor above 90% predicted CRof the primary tumor.
Conclusion: Patients with loco-regionally advanced HPV-positive OPSCC show a goodresponse to neoadjuvant chemotherapy. Neoadjuvant chemotherapy followed by definitive surgery is a new paradigm worthy of further investigation.
- To present a new paradigm in the treatment of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC).
- To ascertain the response to neoadjuvant chemotherapy in a group of patients with locally-advanced HPV-positive oropharyngeal squamous cell carcinoma (OPSCC).
- To evaluate and value the utility of tumor volume reduction on imaging in order to predict pathologic response in patients with HPV-positive OPSCC receiving neoadjuvant chemotherapy.
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Authors' Contact Details
Corresponding Author: Dr. Sarah Khalife
Senior Author: Dr. Nader Sadeghi
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